Endocrine Abstracts

An 85 year old lady was admitted with painless jaundice and cholestatic liver functions (LFTs). Investigations organised by gastroenterologists were fine including hepatitis viral screen, copper and ceruloplasmin levels, alpha -one antitrypsin, alpha -fetoprotein, immunoglobulins, auto-immune screen and ultrasound scan of the liver. In view of palpitations and weight loss, thyroid functions (TFTs) were done and showed biochemical hyperthyroidism: FT4 of 36.8 pmol/L (12–22...

Introduction: Amiodarone is a class III antiarrhythmic agent widely used in the treatment of atrial and ventricular arrhythmias.Amiodarone is known to cause thyroid dysfunction in three ways; amiodarone induced hypothyroidism, amiodarone induced thyrotoxicosis (AIT) type I and type II.We present a case of a patient with AIT type II who subsequently developed hypothyroidism.Case presentation: A 43-year-old man...

A 48-year-old gentleman was referred to the endocrine team with abnormal thyroid function tests (TFTs). His background history included cardiomyopathy complicated by atrial fibrillation (AF). He had been treated with amiodarone for a year. TFTs were monitored regularly during treatment and were normal. Four months after stopping amiodarone, he complained of weight loss, sweating and tremor. He had no family history of thyroid disease. He had a resting heart rate of 120/min (AF...

To evaluate the seminal plasma anti-oxidant activity in normal and infertile men and its relation to semen quality. 58 men with idiopathic infertility problems were selected, were divided according to their sperm count into two subgroups, infertile asthenospermic group (n=31) and infertile oligo-asthenospermic group (n=27). 14 proved fertile men were selected as a control group. Semen samples were collected by masturbation, examined by conventional method. Then f...

Objective: To examine different methods of analysing bone health and body composition in children and examine the relationships between these methods.Method: In a LREC approved cross-sectional study, DXA was used to assess bone mineral content (BMC) (at total body (TB), lumbar spine (LS), femur (F) and femoral neck (FN)), cross-sectional moment of inertia (CSMI) at the proximal femur and body composition (defined as Lean mass (LM) and Fat mass (FM)) in 6...

We present the case of a 65 year old woman with history of difficult to control essential hypertension for many years, and subarachnoid haemmorhage in 1992 requiring insertion of surgical clips for aneurysms at both internal carotid arteries and right middle cerebral arteries.She presented in 2004 with a 3 week history of headaches and a history over one year of increasing size of her hands, feet and nose, goiter and hoarse voice. Serum IGF-1 was 84 nmol...

BackgroundIdiopathic Addisons disease is characterised by the presence of adrenal antibodies and a documented variable subclinical period. In previously well controlled Type 1 diabetes, it may present with recurrent hypoglycaemia, or worsening erratic glycaemic control.Case ReportA 24 year old with previously well controlled Type 1 diabetes since age 18 months presented with worsening glycaemic control, 2 sto...

BackgroundIdiopathic Addisons disease is characterised by the presence of adrenal antibodies and a documented variable subclinical period. In previously well controlled Type 1 diabetes, it may present with recurrent hypoglycaemia, or worsening erratic glycaemic control.Case ReportA 24 year old with previously well controlled Type 1 diabetes since age 18 months presented with worsening glycaemic control, 2 sto...

Section 1: Case history An 86 year old female presented to hospital after being found on the floor and had profound lower limb oedema. She was treated for a urinary tract infection and possible heart failure. On examination she had significant hirsutism and bruised skin. She had a past medical history of BCC removal and primary hyperparathyroidism. Her ECOG performance status was 1–2. There was a family history of pancreatic cancer (father) and pancreatic neuroendocrine tumour...

Following the roll-out of the I-DSD Registry in the 2000s, there was a consensus view that there was a need for a registry for congenital adrenal hyperplasia (CAH) and this was launched in 2014 as a dedicated module within the original registry. There are approximately 150 centres from 50 countries that are currently using the I-DSD/I-CAH/I-TS family of registries and between them there are almost 3,000 cases of CAH that have now been entered. In addition to supporting and pro...